Description

Gramicidin S Hydrochloride is a potent cyclic decapeptide antibiotic derived from the bacterium *Bacillus brevis*. This compound is valued for its strong bactericidal activity, particularly against Gram-positive bacteria, by disrupting the integrity of the cell membrane. It is a critical raw material and research tool for the pharmaceutical, biotechnology, and life science sectors, supporting the development of novel antimicrobial agents and fundamental microbiological studies.

Application

• Pharmaceutical Intermediates: Serves as a key starting material or active component in the research and development of topical antibiotic formulations and combination therapies.
• Biochemical Research: Widely used as a model membrane-active peptide in studies of ion channel formation, membrane permeability, and mechanisms of antimicrobial action.
• Microbiology & Cell Biology: Employed as a selective agent in culture media and in experiments to study bacterial cell lysis, protoplast formation, and membrane biophysics.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and other chromatographic methods to ensure product identity and potency.
• Veterinary Medicine: Investigated for use in topical applications for the treatment of bacterial infections in animals.

Basic Information

Product Name	Gramicidin S Hydrochloride
CAS No.	15207-30-4
Molecular Formula	C60H92N12O10 • xHCl
Molecular Weight	~1141.5 (base) + xHCl
Synonyms	Gramicidin S HCl; Gramicidin Soviet Hydrochloride; Gramicidin S Dihydrochloride; Gramicidin S, Hydrochloride; Gramicidin S from Bacillus brevis hydrochloride; Cyclo(-Val-Orn-Leu-D-Phe-Pro-)2 hydrochloride; Tyrocidine S Hydrochloride; Gramicidin S Monohydrochloride
EINECS	Contact for details

Quality Control

Our Gramicidin S Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for purity (by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions. Keep container tightly sealed when not in use to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0% (anhydrous basis)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
pH (in solution)	3.0 - 5.0
Biological Activity	Confirmed by microbiological assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.