Description

Hydrochlorathiazide-Triamterene CAS NO 14124-50-6 is a fixed-dose combination active pharmaceutical ingredient (API) primarily used as a diuretic and antihypertensive agent. This combination leverages the complementary mechanisms of its two components to enhance efficacy while mitigating potential side effects like hypokalemia. It is a critical raw material for pharmaceutical manufacturers producing combination therapies for the management of edema and hypertension. The product is supplied under stringent quality controls to meet the exacting standards of the global pharmaceutical industry.

Application

• Pharmaceutical Formulation: Primary use as the active ingredient in fixed-dose combination tablets for hypertension and edema management.
• Cardiovascular Therapeutics: Formulation of medications for congestive heart failure to reduce fluid retention (edema).
• Antihypertensive Drugs: Manufacture of combination drugs that lower blood pressure through dual diuretic action.
• Clinical Research: Serves as a reference standard or raw material in bioavailability, stability, and pharmacokinetic studies.
• Generic Drug Production: Key API for manufacturers developing bioequivalent versions of branded combination diuretics.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing fluid balance in animals.

Basic Information

Product Name	Hydrochlorathiazide-Triamterene
CAS No.	14124-50-6
Molecular Formula	C₁₄H₁₁ClN₆O₄S₂ • C₁₂H₁₁N₇
Molecular Weight	664.12 g/mol (combined)
Synonyms	Hydrochlorothiazide and Triamterene; Triamterene and Hydrochlorothiazide; HCTZ-Triamterene; Dyazide (brand name equivalent); Maxzide (brand name equivalent); 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide compound with 2,4,7-triamino-6-phenylpteridine; 3,4-Dihydro-6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide mixture with 2,4,7-triamino-6-phenylpteridine
EINECS	Contact for details

Quality Control

Our Hydrochlorathiazide-Triamterene is manufactured and tested to meet high-purity pharmacopeial standards. Quality assurance protocols are designed to ensure batch-to-batch consistency, identity, potency, and control of impurities. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and microbiological limits are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/ USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.