Description

Colistimethate is a polymyxin antibiotic derivative, specifically the sodium salt of colistin methanesulfonate. This compound is a critical last-resort therapeutic agent for treating multidrug-resistant Gram-negative bacterial infections. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of injectable antibiotic formulations and advanced antimicrobial studies. Colistimethate CAS NO 12705-41-8 represents a high-value active pharmaceutical ingredient (API) where purity and consistency are paramount for patient safety and efficacy.

Application

• Pharmaceutical API: Core ingredient in the manufacture of sterile injectable antibiotics for hospital use.
• Critical Care Medicine: Formulation of last-line defense treatments against infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.
• Veterinary Pharmaceuticals: Used in certain veterinary medicinal products for treating bacterial infections in animals.
• Microbiological Research: Serves as a standard or investigational compound in studies of antibiotic resistance mechanisms and novel drug combinations.
• Reference Standard: Used in quality control laboratories as a certified reference material for assay and impurity testing.

Basic Information

Product Name	Colistimethate
CAS No.	12705-41-8
Molecular Formula	C58H105N16Na5O28S5
Molecular Weight	1749.8 g/mol (for main component)
Synonyms	Colistin Methanesulfonate Sodium; Colistimethate Sodium; Pentasodium Colistimethanesulfonate; Coly-Mycin M; Polymyxin E Methanesulfonate Sodium; CMS-Na; Colistin Sulfomethate Sodium; Multimycin
EINECS	Contact for details

Quality Control

Our Colistimethate is manufactured and tested under a strict quality management system. It is typically produced to meet or exceed relevant pharmacopeial standards such as USP, EP, and JP. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and specific tests for related substances and residual solvents. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance with cGMP guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be protected from humidity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to slightly yellow powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	≥ 77.0% (as Colistin A)
Water Content (KF)	≤ 8.0 %
pH (1% Solution)	6.5 - 8.5
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 10.0%
Bacterial Endotoxins	< 2.5 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.