Description

Siomycin A CAS NO 12656-09-6 is a potent thiopeptide antibiotic known for its specific inhibitory activity against bacterial RNA polymerase. This compound is a critical tool in microbiological research and serves as a valuable reference standard in antibiotic discovery and development programs. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on novel antimicrobial agents and molecular biology studies.

Application

• Antibiotic Research & Development: Used as a reference compound and biochemical tool to study the mechanism of action of RNA polymerase inhibitors and to screen for new antimicrobial agents.
• Molecular Biology Studies: Employed in in vitro transcription assays to investigate gene expression regulation and the function of bacterial transcription machinery.
• Microbiological Assays: Serves as a positive control in antimicrobial susceptibility testing and in studies of bacterial resistance mechanisms.
• Pharmaceutical Reference Standard: Used for the identification, purity assessment, and quantification of siomycin A in analytical method development and quality control.
• Biochemical Pathway Analysis: Aids in the elucidation of biosynthetic pathways for thiopeptide antibiotics.

Basic Information

Product Name	Siomycin A
CAS No.	12656-09-6
Molecular Formula	C~42~H~49~N~13~O~10~S~6~
Molecular Weight	1080.3 g/mol
Synonyms	Siomycin; Antibiotic Siomycin A; NSC 135757; Thiostrepton-group antibiotic; Thiopeptide antibiotic A; L 156,602; Siomycin complex component A
EINECS	Contact for details

Quality Control

Our Siomycin A is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.