Description

Gramicidin A is a linear, channel-forming antibiotic peptide, widely recognized for its potent bactericidal activity against Gram-positive bacteria. Its primary value lies in its ability to disrupt bacterial cell membrane integrity by forming ion channels, leading to cell death. This makes it a critical component in topical pharmaceutical formulations, particularly for ophthalmic and dermatological applications, and a valuable tool in biochemical research for studying membrane transport and ion channel function.

Application

• Topical Pharmaceutical Preparations: A key active ingredient in antibiotic creams, ointments, and eye drops, often combined with other antibiotics like neomycin and polymyxin B for broad-spectrum coverage.
• Biochemical & Biophysical Research: Used extensively as a model compound for studying ion transport mechanisms, membrane permeability, and the biophysics of channel-forming peptides.
• Microbiological Studies: Employed as a selective agent in research to study bacterial membrane structure, function, and resistance mechanisms.
• Veterinary Medicine: Incorporated into topical treatments for skin and eye infections in animals.
• Reference Standard: Serves as a high-purity analytical standard in pharmaceutical quality control and research laboratories for method development and validation.

Basic Information

Product Name	Gramicidin A
CAS No.	11029-61-1
Molecular Formula	C99H140N20O17
Molecular Weight	1882.3 g/mol
Synonyms	Gramicidin A1; Gramicidin A, Valine-; Gramicidin D (major component); Gramicidin, Valine-; Gramicidin A from Bacillus brevis; Gramicidin A Peptide; Gramicidin A (antibiotic); Gramicidin A, Val-Gramicidin A
EINECS	234-255-4

Quality Control

Our Gramicidin A is manufactured and tested under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Biological Activity	Assayed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.