Description

4-(Trifluoromethyl)Benzamide is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its trifluoromethyl group, which imparts unique electronic and steric properties critical for modulating the biological activity and physicochemical characteristics of target molecules. It is primarily needed by pharmaceutical, agrochemical, and material science research and development teams for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, amide bond formations, and as a precursor for other trifluoromethyl-substituted aromatic compounds.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry and material science for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-(Trifluoromethyl)Benzamide
CAS No.	1891-90-3
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	p-(Trifluoromethyl)benzamide; 4-(Trifluoromethyl)benzenecarboxamide; alpha,alpha,α-Trifluoro-p-toluamide; NSC 404080; Benzamide, 4-(trifluoromethyl)-; 4-Carbamoylbenzotrifluoride; p-Trifluoromethylbenzamide
EINECS	217-567-5

Quality Control

Our 4-(Trifluoromethyl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	168 - 172 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.