Description

2-(Trifluoromethyl)Benzenesulfonamide is a high-purity, fluorinated aromatic sulfonamide building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both a sulfonamide group and a strongly electron-withdrawing trifluoromethyl substituent, makes it a versatile intermediate for creating molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients. Its reliable quality and consistent performance are critical for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, such as sulfonated polymers for ion-exchange membranes or high-performance materials.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for constructing complex molecular libraries via reactions at the sulfonamide nitrogen or the aromatic ring.
• Ligand and Catalyst Development: Utilized to synthesize novel ligands for metal catalysis or organocatalysts, leveraging the sulfonamide's coordinating and hydrogen-bonding capabilities.

Basic Information

Product Name	2-(Trifluoromethyl)Benzenesulfonamide
CAS No.	1869-24-5
Molecular Formula	C7H6F3NO2S
Molecular Weight	225.19 g/mol
Synonyms	α,α,α-Trifluoro-o-toluenesulfonamide; 2-(Trifluoromethyl)benzenesulfonic acid amide; o-(Trifluoromethyl)benzenesulfonamide; Benzenesulfonamide, 2-(trifluoromethyl)-; 2-Trifluoromethylphenylsulfonamide; 2-CF3-Benzenesulfonamide; 2-TFMSA
EINECS	217-479-5

Quality Control

Our 2-(Trifluoromethyl)Benzenesulfonamide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.