Description

3-(3-Fluorophenyl)-5-Methylisoxazole-4-Carboxylic Acid is a high-purity fluorinated isoxazole derivative, a crucial advanced pharmaceutical intermediate (API intermediate) and versatile building block in organic synthesis. Its value lies in the unique reactivity of the isoxazole ring and the strategic fluorine substitution, enabling the development of novel bioactive compounds. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated heterocyclic motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and environmental stability.
• Chemical Synthesis Scaffold: Serves as a versatile precursor for further functionalization, including amide coupling, esterification, and nucleophilic substitution reactions to create diverse chemical libraries.
• Material Science Precursor: Potential use in the synthesis of specialty polymers, liquid crystals, or organic electronic materials that require fluorinated aromatic components.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and discovery research in academic institutions and contract research organizations (CROs).

Basic Information

Product Name	3-(3-Fluorophenyl)-5-Methylisoxazole-4-Carboxylic Acid
CAS No.	1736-18-1
Molecular Formula	C11H8FNO3
Molecular Weight	221.19 g/mol
Synonyms	3-(3-Fluorophenyl)-5-methyl-4-isoxazolecarboxylic acid; 5-Methyl-3-(3-fluorophenyl)isoxazole-4-carboxylic acid; 4-Isoxazolecarboxylic acid, 3-(3-fluorophenyl)-5-methyl-; 3-(3-Fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid; 3-(3-Fluorophenyl)-5-methylisoxazol-4-yl carboxylic acid; 3-(m-Fluorophenyl)-5-methylisoxazole-4-carboxylic acid; AI3-52698; BRN 1527636
EINECS	Contact for details

Quality Control

Our 3-(3-Fluorophenyl)-5-Methylisoxazole-4-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity. Standard quality control includes HPLC for assay and purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) documenting all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be kept away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.