Description

Fmoc-o-Tert·Butyl-L-Threoninen-Carboxyanhydride CAS NO 125814-28-0 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and controlled incorporation of L-threonine into complex peptide chains, enabling the production of high-value peptides for research and therapeutic applications. It is an essential building block for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based drugs, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential assembly of peptides, particularly where the threonine side chain hydroxyl group requires protection.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides, including hormones, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation & Labeling: Serves as a precursor for creating peptide tags, probes, and modified biomolecules for diagnostic and imaging applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds and drug candidates.
• Academic & Industrial Research: Essential for fundamental studies in peptide structure-activity relationships (SAR) and protein engineering.
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Fmoc-o-Tert·Butyl-L-Threoninen-Carboxyanhydride
CAS No.	125814-28-0
Molecular Formula	C24H25NO6
Molecular Weight	423.46 g/mol
Synonyms	Fmoc-Thr(OtBu)-NCA; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine N-carboxyanhydride; Fmoc-O-tert-butyl-L-threonine NCA; N-Fmoc-O-tert-butylthreonine N-carboxyanhydride; (2R,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxy)carbonyl)oxy)butanoic acid anhydride; Fmoc-L-Thr(OtBu)-NCA; Fmoc-Thr(tBu)-NCA
EINECS	Contact for details

Quality Control

Our Fmoc-o-Tert·Butyl-L-Threoninen-Carboxyanhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.