Description

Z-L-Leucine n-Carboxyanhydride is a high-purity, protected amino acid derivative specifically engineered for peptide synthesis. This compound serves as a critical building block, enabling the controlled and efficient elongation of peptide chains under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, APIs, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the sequential addition of leucine residues in automated and manual SPPS protocols.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methods for the preparation of short to medium-length peptide sequences.
• Research & Development of Bioactive Peptides: Fundamental for creating peptide libraries for drug discovery, including hormone analogs, antimicrobial peptides, and enzyme inhibitors.
• Production of Custom Peptides: Enables contract research and manufacturing organizations (CROs/CMOs) to produce GMP and non-GMP peptides for clinical and commercial use.
• Synthesis of Peptide Fragments for Conjugation: Used to create specific peptide segments for conjugation to proteins, antibodies, or other carriers (e.g., Peptide-Drug Conjugates).
• Material Science: Potential monomer for the synthesis of peptide-polymer hybrids or biomimetic materials.

Basic Information

Product Name	Z-L-Leucine n-Carboxyanhydride
CAS No.	125814-24-6
Molecular Formula	C14H17NO5
Molecular Weight	279.29 g/mol
Synonyms	Z-Leu-NCA; Nα-Carbobenzoxy-L-leucine N-carboxyanhydride; (S)-4-Methyl-2-(2-oxo-1,3-dioxol-4-yl)amino-1-(phenylmethoxycarbonylamino)pentane; NCA-Z-Leucine; CBZ-L-Leucine NCA; Z-Protected Leucine N-Carboxyanhydride; Leucine NCA Z-derivative; Benzyloxycarbonyl-L-leucine N-carboxyanhydride
EINECS	Contact for details

Quality Control

Our Z-L-Leucine n-Carboxyanhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is analyzed via HPLC, NMR, and IR spectroscopy to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DMSO; sparingly soluble in diethyl ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.