Description

2-Fluoro-3-Methylbutyric Acid is a versatile fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. Its value lies in the strategic introduction of both fluorine and a branched alkyl chain, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atom improves lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, influencing dielectric anisotropy and stability.
• Peptide Modification: Employed to incorporate fluorinated side chains into peptides, enhancing their proteolytic stability and membrane permeability for therapeutic applications.
• Fluorinated Surfactant & Polymer Research: Acts as a monomer or modifier in the development of specialty surfactants and high-performance polymers with unique surface properties.
• Chemical Biology Probes: Utilized in the design of isotopic and fluorinated probes for metabolic pathway tracing and imaging studies.

Basic Information

Product Name	2-Fluoro-3-Methylbutyric Acid
CAS No.	1578-62-7
Molecular Formula	C5H9FO2
Molecular Weight	120.12 g/mol
Synonyms	3-Methyl-2-fluorobutyric Acid; (±)-2-Fluoro-3-methylbutanoic Acid; DL-2-Fluoro-3-methylbutyric Acid; 2-Fluoro-3-methylbutanoic Acid; α-Fluoro-β-methylbutyric Acid; 2-Fluoroisovaleric Acid (common name); 1578-62-7; NSC 406021
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-Methylbutyric Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements of your synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizers. For long-term storage, maintaining the container under an inert atmosphere (e.g., nitrogen) is recommended to preserve purity. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.405 - 1.415
Density (g/mL, 20°C)	1.10 - 1.15

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.