Description

Polymyxin B is a polypeptide antibiotic complex derived from *Bacillus polymyxa*, widely recognized for its potent bactericidal activity against Gram-negative bacteria. Its primary commercial value lies in its critical role as a last-resort therapeutic agent and as a selective agent in microbiological research and cell culture media. This product is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies involved in developing and producing anti-infective treatments and specialized growth media.

Application

• Pharmaceutical Active Ingredient: Used in the formulation of injectable and topical antibiotics for treating severe infections caused by multidrug-resistant organisms like *Pseudomonas aeruginosa*.
• Cell Culture & Microbiology: Serves as a selective agent in cell culture media to prevent bacterial contamination, particularly in mammalian cell culture applications.
• Veterinary Medicine: Incorporated into topical ointments and solutions for treating bacterial infections in animals.
• Research & Development: Utilized as a standard or tool compound in microbiological studies, antibiotic mechanism of action research, and susceptibility testing.
• Combination Therapies: Used in combination with other antibiotics (e.g., bacitracin, neomycin) in topical preparations to broaden the spectrum of antimicrobial coverage.

Basic Information

Product Name	Polymyxin B
CAS No.	1404-26-8
Molecular Formula	C56H98N16O13
Molecular Weight	1203.51 g/mol
Synonyms	Aerosporin; Polymyxin B Sulfate; Polyfax; Polymyxin B1; Polymyxin B2; Polymyxin E (Colistin) is a related but distinct compound; Polmyxin B Sulphate; BP; USP Polymyxin B
EINECS	215-774-7

Quality Control

Our Polymyxin B is manufactured and tested under strict quality management systems. Each batch is analyzed to meet stringent specifications for identity, potency, and purity, referencing pharmacopeial standards such as USP and EP where applicable. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay, related substances, and microbiological purity, is provided with every shipment to ensure full traceability and compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to slightly yellow powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 6500 IU/mg (on dried basis)
Loss on Drying	≤ 7.0 %
pH (1% Solution)	5.0 - 7.5
Related Substances (HPLC)	Total impurities ≤ 5.0%
Bacterial Endotoxins	< 2.0 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.