Antimetabolite Antineoplastic Agents

Antineoplastics

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Antimetabolite Antineoplastic Agents

Antimetabolite antineoplastic agents are structural analogs of nucleotides or essential metabolic substrates that disrupt DNA and RNA synthesis, leading to cell cycle arrest and apoptosis in rapidly dividing tumor cells. Major classes include antifolates, purine analogs, and pyrimidine analogs such as methotrexate, 5-fluorouracil, cytarabine, and gemcitabine. These agents interfere with thymidylate synthase, DNA polymerase, or folate pathways, making them cornerstone therapies in hematologic malignancies and solid tumors including colorectal cancer, lung cancer, and breast cancer. Their ability to selectively target fast-proliferating cells makes them highly effective, though toxicity to bone marrow and gastrointestinal tissues requires careful management.

2-[[(4S)-4-Carboxy-4-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoy L]Amino]Butyl]Carbamoyl]Benzoic Acid CAS NO 113857-87-7

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CAS No.:113857-87-7

Grade:Pharmacy Grade

Content:99.90%

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Mtx-Ala CAS NO 116819-28-4

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CAS No.:116819-28-4

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Content:99.90%

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n-(4-((3-(2,4-Diamino-1,6-Dihydro-6-Oxo-5-Pyrimidinyl)Propyl)Amino)Benzoyl)Glutamic Acid CAS NO 118252-44-1

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CAS No.:118252-44-1

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Content:99.90%

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Aminopterin-Α-Hyrazide CAS NO 118359-33-4

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CAS No.:118359-33-4

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Content:99.90%

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[(2R,3R,4R,5R)-5-(5-Fluoro-2,4-Dioxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxo Lan-2-Yl]Methyl Octanoate CAS NO 118694-10-3

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CAS No.:118694-10-3

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Content:99.90%

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2-Desamino-2-Methylaminopterin CAS NO 118869-52-6

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CAS No.:118869-52-6

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Content:99.90%

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10-Methyl-11-Deazahomofolic Acid CAS NO 119770-55-7

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CAS No.:119770-55-7

Grade:Pharmacy Grade

Content:99.90%

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Nelarabine CAS NO 121032-29-9

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CAS No.:121032-29-9

Grade:Pharmacy Grade

Content:99.90%

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