Description

[[[5-[2,4-dioxo-5-[(E)-3-[3-[2-[5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0 ]oct-2-yl)pentanoylamino]ethyldisulfanyl]propanoylamino]prop-1-enyl]py rimidin-1-yl]-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hyd roxy-phosphoryl]oxyphosphonic acid is a complex, high-purity nucleotide analog with significant biochemical activity. This compound is critical for advanced research and development in targeted therapeutic areas, particularly in the modulation of specific enzymatic pathways. It is primarily sought after by pharmaceutical R&D teams, biotechnology firms, and academic research institutions engaged in the discovery of novel antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Research: Investigated for its potential activity against a range of DNA and RNA viruses in preclinical studies.
• Oncology Research: Used in the development of targeted cancer therapies, particularly those involving nucleotide metabolism inhibition.
• Biochemical Tool Compound: Employed in enzymatic assays and as a probe to study polymerase and kinase functions in mechanistic biology.
• Prodrug Development: Utilized in the design of phosphate and phosphonate prodrugs to enhance cellular uptake and bioavailability.
• Preclinical Candidate Synthesis: A critical raw material for medicinal chemistry programs aiming to optimize pharmacokinetic properties.

Basic Information

Product Name	[[[5-[2,4-dioxo-5-[(E)-3-[3-[2-[5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0 ]oct-2-yl)pentanoylamino]ethyldisulfanyl]propanoylamino]prop-1-enyl]py rimidin-1-yl]-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hyd roxy-phosphoryl]oxyphosphonic acid
CAS No.	97068-12-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GS-441524 triphosphate analog; Remdesivir triphosphate derivative; Nucleotide phosphoramidate; 3'-Hydroxy-2'-deoxy-2'-fluoro-β-D-arabinouridine triphosphate analog; Anti-HCV nucleotide triphosphate; 2'-F-ara-UTP derivative; Bicyclic nucleoside triphosphate; Phosphoramidate prodrug intermediate
EINECS	Contact for details

Quality Control

Our [[[5-[2,4-dioxo-5-[(E)-3-[3-[2-[5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0 ]oct-2-yl)pentanoylamino]ethyldisulfanyl]propanoylamino]prop-1-enyl]py rimidin-1-yl]-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hyd roxy-phosphoryl]oxyphosphonic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.