Description

2',3'-Dideoxy-2',3'-Didehydro-5-Fluoro-Uridine is a fluorinated nucleoside analogue, a key synthetic intermediate in antiviral and anticancer research. This compound matters for its role in the development of novel therapeutic agents, particularly as a precursor for modified nucleosides that target viral polymerases and cellular enzymes. Pharmaceutical R&D laboratories and fine chemical manufacturers specializing in active pharmaceutical ingredients (APIs) require this high-purity intermediate to advance their drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogues.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate polymerase mechanisms and nucleotide metabolism.
• Antiviral Drug Development: Serves as a precursor in the research and development of potential therapeutics targeting viruses such as HIV, HBV, and HCV.
• Oncology Research: Employed in the synthesis of fluoropyrimidine derivatives for evaluating antitumor activity and cell proliferation inhibition.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of complex nucleoside-based APIs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2',3'-Dideoxy-2',3'-Didehydro-5-Fluoro-Uridine
CAS No.	15379-29-0
Molecular Formula	C9H9FN2O5
Molecular Weight	244.18 g/mol
Synonyms	5-Fluoro-2',3'-dideoxy-2',3'-didehydrouridine; 5-Fluoro-d4U; 5-Fluoro-2',3'-didehydro-2',3'-dideoxyuridine; 5-F-d4U; 1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione; 2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine; Fd4U
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-2',3'-Didehydro-5-Fluoro-Uridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.