Description

2,4(1H,3H)-Pyrimidinedione,1-(3-Azido-2,3-Dideoxy-B-D-Threo-Pentofuranosyl)- is a specialized nucleoside analog, a key intermediate in the synthesis of modified oligonucleotides and antiviral agents. Its value lies in its unique azido and dideoxy functional groups, which are critical for "click chemistry" applications and the development of chain-terminating therapeutic compounds. This high-purity building block is essential for pharmaceutical R&D, particularly for companies developing next-generation antiviral drugs, antisense oligonucleotides, and diagnostic probes.

Application

• Antiviral Drug Intermediate: A critical precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oligonucleotide Synthesis: Used as a modified nucleoside phosphoramidite for incorporating specific functionalities into DNA/RNA strands for research and therapeutic applications.
• Click Chemistry Reagent: The azido group enables efficient, bioorthogonal copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and labeling studies.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, nucleic acid metabolism, and polymerase activity.
• Diagnostic Probe Development: Utilized in creating labeled nucleotides for fluorescence in situ hybridization (FISH) and other detection platforms.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies in the search for new therapeutic entities.

Basic Information

Item	Detail
Product Name	2,4(1H,3H)-Pyrimidinedione,1-(3-Azido-2,3-Dideoxy-B-D-Threo-Pentofuranosyl)-
CAS No.	101039-96-7
Molecular Formula	C9H11N5O4
Molecular Weight	253.22 g/mol
Synonyms	3'-Azido-2',3'-dideoxythymidine-5'-triphosphate precursor; 3'-Azido-3'-deoxythymidine intermediate; AZT nucleoside analog; 1-[(2S,5R)-5-(Azidomethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; Azidothymidine derivative; N3-Azido-ddT; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.