Description

[(2R,5R)-5-[(2-Aminoacetyl)Amino]-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is a high-purity, chemically defined nucleotide analog of significant interest in advanced biochemical research and pharmaceutical development. Its precise stereochemistry and functional groups make it a valuable building block for synthesizing novel therapeutic agents and molecular probes. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, enzymology studies, and the development of nucleotide-based prodrugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of nucleoside analog antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Proteomics & Molecular Biology: Serves as a precursor for labeling reagents or affinity probes to study protein-nucleotide interactions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleotide therapeutics.
• Reference Standard: Used as an analytical standard in quality control laboratories for the identification and quantification of related compounds.

Basic Information

Product Name	[(2R,5R)-5-[(2-Aminoacetyl)Amino]-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	10074-18-7
Molecular Formula	C8H15N2O8P
Molecular Weight	298.19 g/mol
Synonyms	N-(2-Aminoacetyl)-2'-C-methylcytidine-3'-phosphate; 2'-C-Methylcytidine-3'-phosphate, N-glycyl-; (2R,5R)-5-[(2-Aminoacetamido)methyl]-3,4-dihydroxyoxolan-2-yl methoxyphosphonic acid; 2'-C-Methyl-N-glycylcytidine 3'-phosphate; A phosphonate derivative of 2'-C-methylcytidine; N-Glycyl-2'-C-methylcytidine 3'-monophosphate
EINECS	Contact for details

Quality Control

Our [(2R,5R)-5-[(2-Aminoacetyl)Amino]-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) documenting full specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.