Description

[5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is a chemically modified nucleotide analog of significant interest in advanced biochemical research and pharmaceutical development. This compound, with CAS number 18839-83-3, serves as a crucial building block and a potential enzyme inhibitor due to its structural similarity to natural nucleotides. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapeutics, and novel molecular probes.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Proteomics & Molecular Biology: Acts as a modified building block for synthesizing oligonucleotide probes or primers for specialized diagnostic and research applications.
• Medicinal Chemistry: Provides a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic Research: Utilized in universities and research institutes for fundamental studies on nucleotide metabolism and signaling pathways.

Basic Information

Product Name	[5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	18839-83-3
Molecular Formula	C10H14N5O7P
Molecular Weight	347.22 g/mol
Synonyms	9-[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(phosphonomethoxy)tetrahydrofuran-2-yl]adenine; PMEA; Adefovir precursor; (R)-9-[2-(Phosphonomethoxy)propyl]adenine intermediate; GS-0393 intermediate; 9-(2-Phosphonylmethoxyethyl)adenine analog; Nucleotide phosphonate analog
EINECS	Contact for details

Quality Control

We supply [5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We can support development projects requiring material that meets stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.