Description

5'-Azido-5'-Deoxythymidine is a chemically modified nucleoside analog, a key synthetic intermediate in medicinal chemistry and life science research. Its unique azido functional group makes it a versatile building block for click chemistry applications, enabling the synthesis of complex biomolecular conjugates. This compound is essential for researchers and manufacturers in pharmaceutical development, oligonucleotide synthesis, and the creation of novel diagnostic probes and targeted therapeutics.

Application

• Click Chemistry Reagent: Acts as a critical precursor for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label or functionalize biomolecules.
• Antiviral Drug Intermediate: Serves as a synthetic building block in the research and development of nucleoside-based antiviral agents.
• Oligonucleotide Modification: Used to introduce azide groups into DNA or RNA strands for subsequent conjugation with dyes, affinity tags, or other functional modules.
• Proteomics & Bioconjugation: Enables site-specific labeling of proteins and other macromolecules for imaging, pull-down assays, and drug delivery system development.
• Chemical Biology Tool: Facilitates the study of cellular processes through metabolic incorporation and subsequent bioorthogonal labeling.
• Polymer & Material Science: Employed in the synthesis of functionalized polymers and smart materials with biological activity.

Basic Information

Product Name	5'-Azido-5'-Deoxythymidine
CAS No.	19316-85-9
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	5'-Azido-5'-deoxythymidine; 3'-Azido-3'-deoxythymidine (structural isomer); AZT precursor; 1-[(2R,4S,5R)-4-Azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 5'-N3-dT; Thymidine 5'-azide; Azidothymidine intermediate; NSC 406140
EINECS	Contact for details

Quality Control

Our 5'-Azido-5'-Deoxythymidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent degradation due to its light-sensitive and easily oxidized nature. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.