Description

Enfuvirtide Acetate CAS NO 914454-00-5 is a synthetic peptide drug substance, the acetate salt form of the HIV fusion inhibitor enfuvirtide. This compound is critical for the formulation of antiretroviral therapies targeting HIV-1 infection. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced antiviral medications and related biomedical research.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of injectable antiretroviral drugs.
• Research and Development of novel HIV-1 fusion inhibitor therapies and combination treatments.
• Biomedical Research as a critical tool for studying viral entry mechanisms and host-pathogen interactions.
• Pharmaceutical Reference Standard for quality control and analytical method development in QC laboratories.
• Formulation Development for stability studies and dosage form optimization.

Basic Information

Product Name	Enfuvirtide Acetate
CAS No.	914454-00-5
Molecular Formula	C204H301N51O64 • xC2H4O2
Molecular Weight	4491.9 g/mol (free base, approximate)
Synonyms	Enfuvirtide acetate salt; T-20 Acetate; DP-178 Acetate; HIV-1 fusion inhibitor T-20; Pentafuside Acetate; Fuzeon® API (Acetate form); N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-glutamyl-L-glutamyl-L-seryl-glutaminyl-L-asparaginyl-glutaminyl-glutaminyl-L-glutamyl-L-lysyl-L-asparaginyl-L-glutamyl-L-glutaminyl-L-glutamyl-L-leucyl-L-leucyl-L-glutamyl-leucyl-L-aspartyl-L-lysyl-L-tryptophyl-L-alanyl-L-seryl-L-leucyl-L-tryptophyl-L-asparaginyl-L-tryptophyl-L-phenylalanyl-L-asparaginyl Acetate
EINECS	Contact for details

Quality Control

Our Enfuvirtide Acetate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, peptide mapping, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against release criteria.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under controlled humidity conditions to maintain stability. For long-term storage, consider desiccant use within the primary container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous, solvent-free basis)
Purity (Related Substances, HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	3.0 - 6.0 moles/mole peptide
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bacterial Endotoxins	< 5.0 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.