Description

5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-(3-hydroxy-2-methyl-butanoyl)sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]-phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a high-purity, complex nucleotide derivative of significant interest in advanced biochemical research and pharmaceutical development. Its intricate molecular structure, featuring multiple functional groups, makes it a valuable precursor and building block for synthesizing novel therapeutic agents and specialized biochemical probes. This compound is essential for researchers and manufacturers in the life sciences sector, particularly those focused on oncology, antiviral therapies, and molecular diagnostics.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and specific cancers.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies and metabolic pathway analysis.
• Pro-drug Development: Serves as a key building block for designing advanced pro-drugs with improved bioavailability and targeted delivery.
• Antiviral Agent Synthesis: Integral component in the research and development pipeline for next-generation antiviral medications.
• Molecular Biology Reagents: Employed in the creation of labeled nucleotides and probes for genetic sequencing and diagnostic assays.
• Enzyme Mechanism Studies: Utilized to investigate the binding and catalytic mechanisms of kinases, polymerases, and other nucleotide-processing enzymes.

Basic Information

Item	Details
Product Name	5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-(3-hydroxy-2-methyl-butanoyl)sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]-phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	52227-66-4
Molecular Formula	C26H43N8O19P3S
Molecular Weight	896.66 g/mol
Synonyms	Adenosine triphosphate derivative; Modified ATP analog; Nucleotide prodrug intermediate; 9H-Purin-6-amine, N-[3-[[2-[[2-[[(3-hydroxy-2-methyl-1-oxobutyl)thio]acetyl]amino]ethyl]amino]-3-oxo-2,2-bis[[(phosphonooxy)methoxy]methyl]propoxy]hydroxyphosphinyl]-2-(hydroxymethyl)-5-(6-oxido-9H-purin-9-yl)tetrahydro-3-furanyl ester; Complex nucleotide thiocarbamate; ATP-thioester conjugate
EINECS	Contact for details

Quality Control

Every batch of this high-value biochemical is produced under strict quality management systems and undergoes comprehensive analytical characterization. We provide full Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and compliance with research-grade specifications. Our commitment to cGMP principles in manufacturing guarantees consistency and reliability for critical pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is hygroscopic (moisture-sensitive); the container must be sealed under an inert atmosphere (argon or nitrogen) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Biological Activity (Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.