Description

Phosphine oxide, [(2Z)-2-[(3R,4R,5R)-3,5-bis[[(1,1-diMethylethyl)dimethylsilyl]oxy]-4-[3-[[(1,1-diMethylethyl)dimethylsilyl]oxy]propoxy]-2-methylenecyclohexylidene]ethyl]diphenyl- is a sophisticated, high-purity organosilicon-protected intermediate of significant importance in advanced organic synthesis. This compound is specifically designed to act as a key chiral building block for the construction of complex molecular architectures. It is essential for research and development chemists working in pharmaceutical discovery and fine chemical manufacturing, particularly for projects requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and antiviral research.
• Asymmetric Synthesis: Used in the construction of complex natural products and other stereochemically demanding molecules due to its defined (3R,4R,5R) configuration.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) ether groups provide orthogonal protection for hydroxyl functions during multi-step synthetic sequences.
• Process Chemistry Development: Serves as a high-value intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories.

Basic Information

Product Name	Phosphine oxide, [(2Z)-2-[(3R,4R,5R)-3,5-bis[[(1,1-diMethylethyl)dimethylsilyl]oxy]-4-[3-[[(1,1-diMethylethyl)dimethylsilyl]oxy]propoxy]-2-methylenecyclohexylidene]ethyl]diphenyl-
CAS No.	200636-54-0
Molecular Formula	C48H79O5PSi3
Molecular Weight	851.37 g/mol
Synonyms	[(2Z)-2-[(3R,4R,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-4-[3-[(tert-butyldimethylsilyl)oxy]propoxy]-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; (3R,4R,5R)-4-[3-[(tert-Butyldimethylsilyl)oxy]propoxy]-3,5-bis[(tert-butyldimethylsilyl)oxy]-2-methylenecyclohexylideneethyldiphenylphosphine oxide; TBDMS-protected phosphine oxide chiral diol derivative; CAS 200636-54-0
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols in a GMP-compliant environment. Every batch is characterized using advanced analytical techniques including HPLC, NMR (1H, 13C, 31P), and chiral analysis to ensure identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee batch-to-batch consistency and support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.