Description

(-)-Methylphenylpropylphosphine Oxide is a chiral organophosphorus compound of significant interest in advanced chemical synthesis. Its value lies in its role as a versatile ligand and chiral auxiliary, enabling precise stereochemical control in catalytic and stoichiometric reactions. This high-purity specialty chemical is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing enantiomerically pure active ingredients.

Application

• Asymmetric Catalysis: Employed as a chiral ligand in transition metal-catalyzed reactions, including hydrogenation and cross-coupling, to produce single-enantiomer intermediates.
• Pharmaceutical Intermediate Synthesis: A key building block and directing agent in the synthesis of complex, optically active drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and pesticides where specific stereochemistry is critical for bioactivity.
• Material Science: Investigated as a component in chiral polymers or as a modifier for surfaces to induce chirality in advanced materials.
• Academic & Process R&D: A valuable tool for methodological development in organic synthesis and for scaling up enantioselective processes.

Basic Information

Product Name	(-)-Methylphenylpropylphosphine Oxide
CAS No.	1515-99-7
Molecular Formula	C10H15OP
Molecular Weight	182.20 g/mol
Synonyms	(-)-Methylphenylpropylphosphine Oxide; (S)-(-)-Methylphenylpropylphosphine Oxide; (S)-Methylphenylpropylphosphine Oxide; P-Methyl-P-phenyl-P-propylphosphine oxide; (S)-(-)-Methylphenylpropylphosphine oxide; Methylphenylpropylphosphine oxide, (-)-; (S)-(-)-Methylphenylpropylphosphine oxide; (S)-(-)-Methylphenylpropylphosphine oxide (enantiomer)
EINECS	Contact for details

Quality Control

Our (-)-Methylphenylpropylphosphine Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and optical rotation measurement, to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]	Contact for details
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.