Description

(S)-(-)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl is a high-value, chiral bidentate ligand belonging to the BINAP family, renowned for its exceptional stereoselectivity in asymmetric catalysis. This compound matters because it enables the precise synthesis of single-enantiomer intermediates, which are critical for developing pharmaceuticals, agrochemicals, and advanced materials with superior efficacy and safety profiles. Industries that require enantiomerically pure compounds, such as pharmaceutical R&D, fine chemical manufacturing, and academic research, rely on this ligand for its proven performance in hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Cross-Coupling Catalysis: Used in asymmetric Suzuki-Miyaura and other C-C bond-forming reactions to construct complex chiral molecules.
• Agrochemical Manufacturing: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A fundamental tool in methodological development for new catalytic transformations in chemistry laboratories.
• Material Science: Potential application in the synthesis of chiral polymers and advanced functional materials with specific optical properties.

Basic Information

Product Name	(S)-(-)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl
CAS No.	74974-15-5
Molecular Formula	C44H34N2P2
Molecular Weight	652.70 g/mol
Synonyms	(S)-(-)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl; (S)-BINAP-Amine; (S)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-binaphthyl; (S)-BINAP-NH2; (S)-H8-BINAP-Diamine; (S)-1,1'-Binaphthyl-2,2'-diamine, N,N'-bis(diphenylphosphino)-, (S)-; (S)-BINAM-DPP; (S)-BINAP-Diamine
EINECS	Contact for details

Quality Control

Our (S)-(-)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and optical purity. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep the container in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.