Description

1,2-Bis((2R,5R)-2,5-Dimethylphospholano)ethane is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in the synthesis of complex, single-enantiomer molecules, a critical requirement in modern pharmaceutical and fine chemical manufacturing. Industrial and academic researchers in the fields of asymmetric hydrogenation and cross-coupling reactions rely on this ligand for its excellent selectivity and efficiency.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the production of enantiomerically pure pharmaceutical intermediates.
• Catalyst component in the synthesis of active pharmaceutical ingredients (APIs) requiring high stereochemical purity.
• Use in asymmetric C-C bond formation reactions, such as cross-couplings and additions.
• Critical reagent for academic and industrial R&D in organometallic chemistry and catalysis.
• Production of specialty fine chemicals and agrochemicals where chirality impacts biological activity.
• Development of novel catalytic systems for green chemistry and sustainable synthesis pathways.

Basic Information

Product Name	1,2-Bis((2R,5R)-2,5-Dimethylphospholano)ethane
CAS No.	638132-66-8
Molecular Formula	C14H28P2
Molecular Weight	258.32 g/mol
Synonyms	(R,R)-Me-DuPhos; (2R,2'R,5R,5'R)-1,1',2,2',5,5',6,6'-Octahydro-3,3',4,4'-tetramethyl-2,2'-biphosphinine; 1,2-Bis((2R,5R)-2,5-dimethylphospholano)ethane; (R,R)-1,2-Bis(2,5-dimethylphospholano)ethane; DuPhos ligand (R,R)-isomer; (R,R)-Me-DuPhos ligand; (2R,5R)-2,5-Dimethylphospholane ethane dimer
EINECS	Contact for details

Quality Control

Our production of 1,2-Bis((2R,5R)-2,5-Dimethylphospholano)ethane adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for catalytic performance. All materials are fully characterized, and Certificates of Analysis (COA) detailing identity, purity, and chiral integrity are provided with every shipment. We support compliance with cGMP and ISO quality management standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), this product must be stored under an inert gas (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed to exclude moisture and oxygen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.