Description

(2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol is a sophisticated nucleoside analog derivative, engineered for high-affinity binding and modulation of specific biological targets. This compound matters for its potential as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics, particularly in oncology and antiviral research. Pharmaceutical R&D laboratories and advanced fine chemical manufacturers need this high-purity building block to drive innovation in drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based therapeutics.
• Drug Discovery & Development: Used in high-throughput screening and as a reference standard in target validation studies for oncology and virology.
• Biochemical Research: Employed as a tool compound to study enzyme inhibition, receptor binding, and cellular signaling pathways.
• Preclinical Studies: Utilized in the formulation and testing of potential drug candidates in animal models.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Proteomics & Molecular Biology: Potential use in the development of labeled probes or affinity purification reagents.

Basic Information

Product Name	(2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
CAS No.	1380288-88-9
Molecular Formula	C₃₁H₄₄N₈O₃
Molecular Weight	564.73 g/mol
Synonyms	9H-Purin-6-amine, 9-[(2R,3R,4S,5R)-5-[[[(1r,3S)-3-[2-[5-(1,1-Dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]methyl]-3,4-dihydroxy-2-tetrahydrofuranyl]-; Modified Nucleoside Derivative; Tert-butyl-benzimidazole nucleoside analog; Cyclobutyl-linked purine derivative; Isopropylamino-methyl tetrahydrofuran diol purine; Advanced Pharmaceutical Intermediate 1380288-88-9
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically assessed via HPLC, NMR, and MS. Specifications can be aligned with research-grade or cGMP standards based on customer requirements for preclinical and clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.