Description

2-Di-t-butylphosphino-4-Methoxy-3,5,6-triMethyl-2',4',6'-tri-i-propylbiphenyl, Min. 98% [~1:1 Mixture with regioisoMer, 2-Di-t-butylphosphino-5-Methoxy-3,4,6-triMethyl-2',4',6'-tri-i-propylbiphenyl] is a high-purity, sterically hindered biphenylphosphine ligand, supplied as a mixture of regioisomers. This compound is a critical catalyst component in cross-coupling reactions, prized for its ability to facilitate challenging transformations with high efficiency and selectivity. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance ligands for metal-catalyzed synthesis.

Application

• Catalyst Ligand in Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings for C–N and C–C bond formation.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the catalytic synthesis of novel herbicides, fungicides, and insecticides.
• Materials Science Research: Facilitates the development of organic electronic materials, polymers, and liquid crystals through controlled coupling reactions.
• Academic & Industrial R&D: A valuable tool for method development and exploring new catalytic pathways in organic synthesis.
• Fine Chemical Production: Applied in the manufacture of specialty and performance chemicals requiring precise molecular architecture.

Basic Information

Item	Details
Product Name	2-Di-t-butylphosphino-4-Methoxy-3,5,6-triMethyl-2',4',6'-tri-i-propylbiphenyl, Min. 98% [~1:1 Mixture with regioisoMer, 2-Di-t-butylphosphino-5-Methoxy-3,4,6-triMethyl-2',4',6'-tri-i-propylbiphenyl]
CAS No.	1359986-21-2
Molecular Formula	C35H55OP
Molecular Weight	522.79 g/mol
Synonyms	Biphenylphosphine Ligand; BrettPhos Precursor; 2-(Di-tert-butylphosphino)-3',5'-diisopropyl-4-methoxybiphenyl (isomeric mixture); t-BuBrettPhos; DTBP-BIPHEP derivative; Sterically hindered phosphine ligand; CAS 1359986-21-2 (Mixture); 2-Di-tert-butylphosphino-4-methoxy-3,5,6-trimethyl-2',4',6'-triisopropyl-1,1'-biphenyl (mixed isomers)
EINECS	Contact for details

Quality Control

Every batch of our phosphine ligand is manufactured and tested under strict quality management protocols to ensure consistent high purity and performance. We guarantee a minimum purity of 98% (by HPLC/NMR) for the specified isomeric mixture. Comprehensive analytical testing, including NMR (1H, 31P, 13C), HPLC, and GC, is performed to verify identity, purity, and isomeric ratio. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity, this material is easily oxidized and must be stored under an inert atmosphere (argon or nitrogen). Recommended storage temperature is 2-8°C for long-term stability. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	Min. 98.0% (total isomeric content)
Isomeric Ratio (HPLC/NMR)	~1:1 mixture of specified regioisomers
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.