Description

(R,R)-ANDEN-Phenyl Trost Ligand, also known as (+)-(11R,12R)Bis[2′-(diphenylphosphino)benzamido]-9,10-dihydro-9,10-ethanoanthracene, is a highly sophisticated chiral ligand pivotal for enabling selective chemical transformations. This compound is essential for achieving high enantioselectivity in asymmetric synthesis, a cornerstone of modern pharmaceutical and fine chemical manufacturing. It is a critical tool for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: As a premier ligand for palladium-catalyzed asymmetric allylic alkylation (AAA) reactions, enabling the construction of chiral carbon centers.
• Pharmaceutical Intermediate Synthesis: For the enantioselective synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Production: In the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Fine Chemical Manufacturing: For producing high-value chiral intermediates used in flavors, fragrances, and electronic chemicals.
• Methodology Development: A key reagent in academic and industrial R&D for developing new catalytic asymmetric methodologies.
• Process Chemistry Optimization: Used to scale up enantioselective reactions from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(R,R)-ANDEN-Phenyl Trost Ligand
CAS No.	152140-65-3
Molecular Formula	C66H52N2O2P2
Molecular Weight	967.07 g/mol
Synonyms	(+)-(11R,12R)Bis[2′-(diphenylphosphino)benzamido]-9,10-dihydro-9,10-ethanoanthracene; (11R,12R)-N,N′-(9,10-Dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)benzamide]; (R,R)-ANDEN-Phenyl Trost Ligand; Trost Ligand ANDEN-Phenyl; (R,R)-DACH-Phenyl Trost Ligand derivative; Chiral Diphosphine Ligand; Asymmetric Allylic Alkylation Ligand
EINECS	Contact for details

Quality Control

Every batch of our (R,R)-ANDEN-Phenyl Trost Ligand is manufactured and tested under strict quality management systems to ensure exceptional purity and chiral integrity, suitable for demanding catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation via advanced analytical techniques. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.