Description

[(2R,3R,4R,5R)-3-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3-hydroxy-4,5-diphosphonooxy-oxan-2-yl]oxy-5-(6-aminopurin-9-yl)-4-hydroxy-oxolan-2-yl]methoxyphosphonic acid is a high-purity, chemically defined nucleotide analog of significant interest in advanced biochemical research and pharmaceutical development. This compound is valued for its role as a potent and specific modulator of nucleotide-dependent enzymes and signaling pathways. It is primarily sought after by researchers and developers in the life sciences, pharmacology, and biotechnology sectors for creating novel therapeutic agents and investigative tools.

Application

• Biochemical Research: As a critical substrate or inhibitor in enzymatic studies, particularly for kinases, polymerases, and other nucleotide-binding proteins.
• Pharmaceutical R&D: Serving as a key intermediate or active pharmaceutical ingredient (API) in the development of antiviral, anticancer, or metabolic disorder therapeutics.
• Proteomics & Molecular Biology: Utilization in labeling, cross-linking, or probing experiments to study protein-nucleic acid interactions and cellular signaling mechanisms.
• Diagnostic Reagent Development: Incorporation into assay kits for detecting specific enzymatic activities or as a component in high-throughput screening (HTS) platforms.
• Precision Medicine: Investigation of its role in personalized treatment strategies targeting specific genetic or metabolic pathways.
• Academic Research: Fundamental studies in universities and research institutes exploring nucleotide metabolism, cell cycle regulation, and signal transduction.

Basic Information

Product Name	[(2R,3R,4R,5R)-3-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3-hydroxy-4,5-diphosphonooxy-oxan-2-yl]oxy-5-(6-aminopurin-9-yl)-4-hydroxy-oxolan-2-yl]methoxyphosphonic acid
CAS No.	149091-93-0
Molecular Formula	C18H27N5O19P4
Molecular Weight	735.32 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3-[[(2R,3R,4S,5R,6R)-6-(Acetyloxymethyl)-3,4-dihydroxy-5-(phosphonooxy)oxan-2-yl]oxy]-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurine-2-yl-diphosphate; Adenosine 5'-[P1-[3-acetyl-2,5-dihydroxy-6-(hydroxymethyl)-4-(phosphonooxy)oxanyl]] P2-(2,3,4-trihydroxy-5-[[6-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]methoxy]butyl) ester; Modified Nucleotide Diphosphate Analog; Acetylated Phosphorylated Adenosine Derivative
EINECS	Contact for details

Quality Control

Our [(2R,3R,4R,5R)-3-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3-hydroxy-4,5-diphosphonooxy-oxan-2-yl]oxy-5-(6-aminopurin-9-yl)-4-hydroxy-oxolan-2-yl]methoxyphosphonic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach ambient temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.