Description

[[[(2R,3R,4R,5R)-5-(3-amino-5-oxo-4,7,9-triazabicyclo[4.3.0]nona-2,7,10-trien-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid is a high-purity, complex nucleotide analog with significant biochemical activity. This compound is critical for advanced research and development in life sciences, serving as a key building block or intermediate for novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on antiviral, anticancer, or genetic research.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthetic precursor in the development of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleotide processing.
• Proteomics & Genomics: Employed in the synthesis of specialized probes or primers for genetic sequencing and molecular diagnostics.
• Antisense Technology: Acts as a modified nucleotide in the synthesis of antisense oligonucleotides for targeted gene silencing.
• Enzyme Mechanism Studies: Utilized to study the structure and function of polymerases, kinases, and other nucleotide-binding enzymes.
• Reference Standard: Provides a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	[[[(2R,3R,4R,5R)-5-(3-amino-5-oxo-4,7,9-triazabicyclo[4.3.0]nona-2,7,10-trien-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
CAS No.	103122-85-6
Molecular Formula	C11H17N5O14P3
Molecular Weight	560.19 g/mol
Synonyms	9-(5-O-Phosphono-β-D-ribofuranosyl)guanine 5'-(trihydrogen diphosphate); P1-(9-(5-O-Phosphono-β-D-ribofuranosyl)guanin-5'-yl) P3-trihydrogen diphosphate; GMP-PCP; Guanosine 5'-(beta,γ-methylene)triphosphate; beta,γ-Methylene-guanosine-5'-triphosphate; Guanylyl methylenediphosphonate; beta,γ-CH2-GTP; GMPPCP
EINECS	Contact for details

Quality Control

Our [[[(2R,3R,4R,5R)-5-(3-amino-5-oxo-4,7,9-triazabicyclo[4.3.0]nona-2,7,10-trien-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.