Description

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-2,2-dimethyl-3-[2-[2-(2-methylpropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a high-purity, chemically defined nucleotide derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block or intermediate for the synthesis of modified oligonucleotides and nucleotide-based therapeutics. It is primarily sought by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in developing novel drug candidates, diagnostic probes, and tools for molecular biology.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleotide analogs for antiviral or anticancer drug development.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-phase synthesis building block to introduce specific functionalities into DNA/RNA sequences.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, or other nucleotide-processing enzymes.
• Probe Development: Enables the creation of labeled nucleotides for diagnostic assays, fluorescence in situ hybridization (FISH), and other detection methodologies.
• Antisense & RNA Therapeutics: Potential use in the development of antisense oligonucleotides (ASOs) and siRNA constructs with enhanced stability or targeting properties.
• Enzyme Mechanism Studies: A tool compound for investigating the structure-activity relationships and catalytic mechanisms of nucleotide-binding proteins.

Basic Information

Item	Detail
Product Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-2,2-dimethyl-3-[2-[2-(2-methylpropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	15621-60-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-; dATP analog; Modified deoxyadenosine triphosphate; Nucleotide prodrug intermediate; Custom nucleotide derivative; [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-2-({hydroxy[hydroxy(3-{3-hydroxy-2,2-dimethyl-3-[(2-{2-[(2-methylpropanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy)phosphoryl]oxy}phosphoryl)oxymethyl]oxolan-3-yl]oxyphosphonic acid
EINECS	Contact for details

Quality Control

Our production of this high-value nucleotide derivative adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by weight)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.