Description

Tetramethyl6,6'-Bis(Diphenylphosphino)-1,1',3,3'-Tetrahydro[5,5']Biindenyl-2,2',2,2'-Tetracarboxylate is a sophisticated, chiral diphosphine ligand designed for advanced asymmetric catalysis. This compound matters for its exceptional ability to induce high enantioselectivity and catalytic activity in transition metal complexes, enabling the synthesis of complex chiral molecules. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component for enantioselective C-C bond formation reactions, such as cross-coupling and allylic substitution.
• Used in the synthesis of optically active agrochemicals and flavors/fragrances.
• Critical for developing homogeneous catalytic processes in academic and industrial research.
• Employed in the preparation of chiral metal complexes for material science applications.
• Facilitates high-throughput screening of new catalytic systems in discovery chemistry.

Basic Information

Product Name	Tetramethyl6,6'-Bis(Diphenylphosphino)-1,1',3,3'-Tetrahydro[5,5']Biindenyl-2,2',2,2'-Tetracarboxylate
CAS No.	959864-39-2
Molecular Formula	C58H48O8P2
Molecular Weight	934.93 g/mol
Synonyms	MeO-BIPHEP Tetracarboxylate Derivative; Tetramethyl 6,6'-Bis(diphenylphosphino)-1,1',3,3'-tetrahydro-5,5'-biindene-2,2',2,2'-tetracarboxylate; (R)- or (S)-DTBM-MeO-BIPHEP Tetracarboxylate Analog; Chiral Diphosphine Ligand 959864-39-2; Axially Chiral Biaryl Diphosphine; BIPHEP-Type Ligand with Ester Substituents; Asymmetric Hydrogenation Ligand; CAS 959864-39-2
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and chiral integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity (by HPLC/NMR), and identity confirmation. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated place separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.