Description

Beclabuvir is a potent and selective non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. This compound is a critical intermediate and reference standard in the research and development of novel antiviral therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on virology and drug discovery for HCV treatment.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control of antiviral drug substances and products.
• Drug Discovery & Development: Used as a key biochemical tool and intermediate in the synthesis and optimization of novel NS5B polymerase inhibitors for HCV therapy.
• Mechanistic & Biochemical Research: Employed in in vitro studies to investigate viral replication mechanisms, resistance profiles, and the structure-activity relationship (SAR) of polymerase inhibitors.
• Preclinical Studies: Utilized as a benchmark compound in antiviral efficacy and toxicity screening assays during the preclinical phase of drug development.

Basic Information

Product Name	Beclabuvir
CAS No.	958002-33-0
Molecular Formula	C₂₀H₂₀FN₅O₃
Molecular Weight	397.40 g/mol
Synonyms	BMS-791325; (1R,3aS,6aS)-2-[(2S)-2-{[5-(2,5-Difluorophenyl)-1H-imidazol-2-yl]carbonyl}-2-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-3-methyl-3,4-dihydro-1H-pyrazino[2,1-c][1,4]oxazine-7,8-dione; BMS 791325; BMS791325; NS5B Polymerase Inhibitor BMS-791325
EINECS	Contact for details

Quality Control

Our Beclabuvir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis to ensure it meets high-grade standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.