Description

4-Nitro-3-Trifluoromethyl-Benzoic Acid Methyl Ester is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound is particularly significant for introducing both nitro and trifluoromethyl functional groups into target molecules, which are key motifs in modern agrochemical and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a key fluorinated aromatic component for creating advanced electronic and optoelectronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution to construct complex, functionalized aromatic systems.
• Dye & Pigment Intermediate: Utilized in the production of specialized, high-performance colorants with improved lightfastness and chemical resistance.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorinated units into polymer chains, enhancing material properties like solvent resistance and thermal stability.

Basic Information

Product Name	4-Nitro-3-Trifluoromethyl-Benzoic Acid Methyl Ester
CAS No.	957207-00-0
Molecular Formula	C9H6F3NO4
Molecular Weight	249.14 g/mol
Synonyms	Methyl 4-Nitro-3-(trifluoromethyl)benzoate; Benzoic acid, 4-nitro-3-(trifluoromethyl)-, methyl ester; 3-Trifluoromethyl-4-nitrobenzoic acid methyl ester; Methyl 3-trifluoromethyl-4-nitrobenzoate; 4-Nitro-α,α,α-trifluoro-m-toluic acid methyl ester; Methyl 4-nitro-α,α,α-trifluoro-m-toluate; 957207-00-0; Methyl 4-nitro-3-trifluoromethylbenzoate
EINECS	Contact for details

Quality Control

Our 4-Nitro-3-Trifluoromethyl-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere such as nitrogen or argon to preserve purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.