Description

2-(Methylthio)-5-(Trifluoromethoxy)Phenylboronic Acid is a specialized organoboron compound used as a key synthetic building block in cross-coupling reactions. Its molecular structure, featuring both a methylthio and a trifluoromethoxy substituent, makes it a valuable precursor for introducing unique functional groups into target molecules. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring the (trifluoromethoxy)phenyl moiety.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the specific substitution pattern confers desirable biological activity.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid partner for forming carbon-carbon bonds with aryl halides, enabling the construction of complex biaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs or semiconductors, where the electron-withdrawing trifluoromethoxy group can tune electronic properties.
• Ligand and Catalyst Development: Useful for creating novel ligands for transition metal catalysis or as a precursor for functionalized materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(Methylthio)-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	957121-11-8
Molecular Formula	C8H8BF3O3S
Molecular Weight	252.02 g/mol
Synonyms	[2-(Methylsulfanyl)-5-(trifluoromethoxy)phenyl]boronic acid; 2-Methylthio-5-trifluoromethoxyphenylboronic acid; 5-(Trifluoromethoxy)-2-(methylthio)benzeneboronic acid; 2-Methylsulfanyl-5-trifluoromethoxybenzeneboronic acid; B-[2-(Methylthio)-5-(trifluoromethoxy)phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 2-(Methylthio)-5-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance in sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.