Description

2-Trifluoromethylphenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling the efficient construction of complex molecules through palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is particularly critical for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require the precise introduction of a trifluoromethylphenyl moiety to modulate the properties of target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the CF3 group enhances metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides, where the trifluoromethyl group is a common pharmacophore for improving biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its ability to influence molecular polarity and packing.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart unique thermal, chemical, or surface properties for high-performance coatings and engineering plastics.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for drug discovery.
• Ligand & Catalyst Development: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis and other specialized catalytic processes.

Basic Information

Product Name	2-Trifluoromethylphenylboronic Acid
CAS No.	1423-27-4
Molecular Formula	C7H6BF3O2
Molecular Weight	189.93 g/mol
Synonyms	(2-(Trifluoromethyl)phenyl)boronic acid; 2-(Trifluoromethyl)benzeneboronic acid; o-Trifluoromethylphenylboronic acid; 2-Trifluoromethylbenzeneboronic Acid; Boronic acid, B-[2-(trifluoromethyl)phenyl]-; 2-CF3-PhB(OH)2; 2-Trifluoromethylphenylboronic acid pinacol ester (common derivative); α,α,α-Trifluoro-o-tolylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports applications in cGMP and other regulated environments where traceability and consistency are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.