Description

4-Carboxy-3-Fluorophenylboronic Acid is a multifunctional boronic acid derivative that serves as a key building block in modern synthetic chemistry. Its value lies in the unique combination of a boronic acid group for Suzuki-Miyaura cross-coupling reactions and a carboxylic acid moiety for further derivatization, enabling the construction of complex fluorinated aromatic structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials where the introduction of fluorine atoms is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the fluorophenyl moiety enhances efficacy and environmental stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, sensors, and tools for studying biological processes, leveraging its boronic acid group for selective binding.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl linkages, a cornerstone reaction in medicinal chemistry.
• Derivatization & Conjugation: The carboxylic acid group allows for easy amide bond formation or esterification, facilitating conjugation to other molecules, surfaces, or solid supports.

Basic Information

Product Name	4-Carboxy-3-Fluorophenylboronic Acid
CAS No.	120153-08-4
Molecular Formula	C7H6BFO4
Molecular Weight	183.93 g/mol
Synonyms	(3-Fluoro-4-carboxyphenyl)boronic acid; 3-Fluoro-4-boronobenzoic acid; 4-Borono-3-fluorobenzoic acid; 3-Fluoro-4-carboxybenzeneboronic acid; B-(3-Fluoro-4-carboxyphenyl)boronic acid; 3-Fluoro-4-(dihydroxyboryl)benzoic acid; 120153-08-4; 4-Carboxy-3-fluorobenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Carboxy-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.