Description

2-Fluoro-5-(Trifluoromethyl)Benzenesulphonyl Chloride is a high-value, multi-functional aromatic sulfonyl chloride derivative. This compound serves as a critical synthetic building block and key intermediate in advanced organic synthesis, prized for its ability to introduce both fluorine and sulfonyl functionalities. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science: Building block for specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research: Versatile reagent for introducing the sulfonyl chloride group into complex molecules for further functionalization.
• Dye and Pigment Manufacturing: Intermediate in the production of specialized colorants and fluorescent markers.
• Cross-coupling Reactions: Used in palladium-catalyzed reactions (e.g., Suzuki, Stille) to create biaryl structures for drug discovery.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Benzenesulphonyl Chloride
CAS No.	1744-43-0
Molecular Formula	C7H3ClF4O2S
Molecular Weight	262.61 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-p-toluenesulfonyl chloride; 2-Fluoro-5-(trifluoromethyl)benzenesulfonyl chloride; 5-(Trifluoromethyl)-2-fluorobenzenesulfonyl chloride; 2-Fluoro-α,α,α-trifluoro-p-toluenesulphonyl chloride; 2-Fluoro-5-trifluoromethylbenzenesulfonyl chloride; 2-Fluoro-5-(trifluoromethyl)phenylsulfonyl chloride; Benzenesulfonyl chloride, 2-fluoro-5-(trifluoromethyl)-; 2-Fluoro-α,α,α-trifluoro-p-toluenesulfonyl chloride
EINECS	217-118-7

Quality Control

Our 2-Fluoro-5-(Trifluoromethyl)Benzenesulphonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, GC, and NMR, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.