Description

2-Fluorophenylboronic Acid is a versatile organoboron compound widely used as a key building block in modern synthetic chemistry. Its primary value lies in its role as a crucial coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the 2-fluorophenyl moiety imparts specific biological activity and stability.
• Material Science: Serves as a monomer or functionalization agent in the production of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The primary application is as a boron reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling with organic halides to form carbon-carbon bonds.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in lead optimization, scaffold hopping, and library synthesis.
• Ligand Synthesis: Can be utilized to prepare specialized ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Fluorophenylboronic Acid
CAS No.	1193-03-9
Molecular Formula	C6H6BFO2
Molecular Weight	139.92 g/mol
Synonyms	(2-Fluorophenyl)boronic Acid; 2-Fluorobenzeneboronic Acid; o-Fluorophenylboronic Acid; B-(2-Fluorophenyl)boronic Acid; 2-Fluorophenyl-Boronic Acid; 2-Fluoroborophenol; 2-Fluoro Benzeneboronic Acid; 2-F-C6H4B(OH)2
EINECS	214-777-8

Quality Control

Our 2-Fluorophenylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, and we support our clients' regulatory needs for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.