Description

3-(Methylthio)-5-(Trifluoromethyl)Phenylboronic Acid is a high-purity organoboron compound serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the boronic acid functional group for cross-coupling reactions and the methylthio and trifluoromethyl substituents, which impart specific electronic and steric properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex aryl and heteroaryl structures via Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfur and fluorine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group is a common pharmacophore for efficacy.
• Material Science Research: Building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for studying biological pathways.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-(Methylthio)-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	957120-83-1
Molecular Formula	C8H8BF3O2S
Molecular Weight	235.02 g/mol
Synonyms	[3-(Methylsulfanyl)-5-(trifluoromethyl)phenyl]boronic acid; 3-Methylthio-5-trifluoromethylbenzeneboronic acid; 5-Trifluoromethyl-3-methylthiobenzeneboronic acid; 3-Methylmercapto-5-trifluoromethylphenylboronic acid; Boronic acid, B-[3-(methylthio)-5-(trifluoromethyl)phenyl]-; 3-(Methylthio)-5-(trifluoromethyl)benzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Methylthio)-5-(Trifluoromethyl)Phenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports compliance in cGMP and ISO 9001 environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.