Description

5-Bromo-2-Fluoro-3-Methylphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the halogen and fluorine substituents for enhanced bioactivity and stability.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the bromo-fluoro-methyl substitution pattern tunes electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors for target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex fragments in multi-step synthesis projects.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-Methylphenylboronic Acid
CAS No.	957120-61-5
Molecular Formula	C7H7BBrFO2
Molecular Weight	231.85 g/mol
Synonyms	(5-Bromo-2-fluoro-3-methylphenyl)boronic acid; 2-Fluoro-5-bromo-3-methylbenzeneboronic acid; 3-Borono-5-bromo-2-fluorotoluene; 5-Bromo-2-fluoro-m-tolylboronic acid; Boronic acid, B-(5-bromo-2-fluoro-3-methylphenyl)-; 957120-61-5; 5-Br-2-F-3-MeC6H2B(OH)2
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-3-Methylphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.