Description

2-(Trifluoromethyl)-4-Iodobenzoic Acid is a high-value, multi-functional aromatic building block containing both iodine and trifluoromethyl substituents. This compound matters for its unique reactivity profile, where the iodine atom serves as an excellent handle for cross-coupling reactions, and the trifluoromethyl group imparts desirable properties like enhanced metabolic stability and lipophilicity to final molecules. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the CF₃ group can improve biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The aryl iodide moiety is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Sonogashira, Heck) for constructing complex biaryl and conjugated systems.
• Fluorine Chemistry: An important reagent for introducing the trifluoromethylated benzoic acid scaffold into molecules, a common motif in drug discovery.
• Chemical Biology & Diagnostics: Can be used to create probes, tags, or linkers for studying biological processes or developing diagnostic assays.

Basic Information

Product Name	2-(Trifluoromethyl)-4-Iodobenzoic Acid
CAS No.	954815-11-3
Molecular Formula	C₈H₄F₃IO₂
Molecular Weight	316.02 g/mol
Synonyms	4-Iodo-2-(trifluoromethyl)benzoic Acid; 2-Trifluoromethyl-4-iodobenzoic Acid; Benzoic acid, 4-iodo-2-(trifluoromethyl)-; 4-Iodo-α,α,α-trifluoro-o-toluic Acid; 954815-11-3; 2-CF3-4-I-C6H3-COOH
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-4-Iodobenzoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications in GMP and ISO-regulated environments, ensuring reliable supply for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.