Description

Delcasertib is a potent and selective small-molecule inhibitor of p53-binding protein 1 (53BP1), a key regulator of the DNA damage response pathway. This compound is of significant interest for its potential to modulate cellular responses to genotoxic stress and enhance the efficacy of certain cancer therapies. It is primarily utilized by pharmaceutical researchers and development teams in the fields of oncology and molecular biology for preclinical studies and drug discovery programs.

Application

• Oncology Research: Investigated as a chemosensitizer to improve the effectiveness of DNA-damaging anticancer agents like ionizing radiation and certain chemotherapeutics.
• Mechanistic Studies: Used as a research tool to study the role of the 53BP1 protein in DNA repair mechanisms, particularly non-homologous end joining (NHEJ).
• Drug Discovery: Serves as a lead compound or reference standard in the development of novel targeted cancer therapies that aim to inhibit DNA damage repair pathways.
• Biomarker Research: Employed in cellular assays to understand tumor sensitivity and resistance mechanisms related to DNA repair proficiency.
• Academic Research: Utilized in university and institutional labs for fundamental research into cell cycle regulation, genomic stability, and apoptosis.

Basic Information

Product Name	Delcasertib
CAS No.	949100-39-4
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	53BP1 Inhibitor; KU-55933 Derivative; p53BP1 Inhibitor; 2-(4-{[(3S)-3-Methyl-4-(morpholin-4-ylcarbonyl)piperazin-1-yl]carbonyl}phenyl)-1,3-benzothiazole-6-carboxylic Acid; NSC 781721; DB05880
EINECS	Contact for details

Quality Control

Our Delcasertib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.