Description

Candoxatrilat is the active diacid metabolite of the prodrug candoxatril, functioning as a potent and selective inhibitor of neutral endopeptidase (NEP). This compound is of significant interest in pharmaceutical research for its role in modulating the degradation of natriuretic peptides, which are key regulators of blood pressure and fluid balance. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel cardiovascular therapeutics, including treatments for hypertension and heart failure. The product is supplied under the identifier Candoxatrilat CAS NO 123898-42-0.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in drug development and manufacturing.
• Cardiovascular Research: A critical tool for in vitro and in vivo studies investigating the neutral endopeptidase (NEP) pathway and its effects on vasodilation and natriuresis.
• Metabolite Studies: Used in pharmacokinetic and metabolic profiling research related to the prodrug candoxatril.
• Enzyme Inhibition Assays: Employed in biochemical screening to evaluate the potency and selectivity of new NEP inhibitor candidates.
• Preclinical Development: Supports formulation studies and safety assessments for next-generation cardiovascular agents.

Basic Information

Product Name	Candoxatrilat
CAS No.	123898-42-0
Molecular Formula	C23H30N2O6
Molecular Weight	430.50 g/mol
Synonyms	(2R,4R)-4-([1,1'-Biphenyl]-4-yl)-2-[(phenylmethoxy)carbonyl]pentanedioic acid; UK-73967; Candoxatrilat diacid; UK 73967; (2R,4R)-4-([1,1'-Biphenyl]-4-yl)-2-[(benzyloxy)carbonyl]pentanedioic acid; UK73967
EINECS	Contact for details

Quality Control

Our Candoxatrilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.