Description

Ecadotril is a synthetic neutral endopeptidase (NEP) inhibitor, a compound of significant interest in pharmaceutical research and development. Its primary value lies in its potential as a therapeutic agent for cardiovascular and renal conditions, acting by modulating the activity of key endogenous peptides. This makes it a critical intermediate and reference standard for researchers and manufacturers in the global pharmaceutical industry, particularly those focused on developing treatments for hypertension and heart failure. The compound is identified by CAS No. 112573-73-6.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting neutral endopeptidase.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays and pharmacological studies to investigate NEP inhibition pathways.
• Cardiovascular Drug Development: Serves as a precursor or model compound in R&D programs for novel antihypertensive and vasodilatory agents.
• Reference Material: Employed in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Academic Research: Utilized in university and institutional labs for studying peptide metabolism and the renin-angiotensin system.

Basic Information

Product Name	Ecadotril
CAS No.	112573-73-6
Molecular Formula	C18H28N2O4
Molecular Weight	336.43 g/mol
Synonyms	Sinorphan; (S)-N-[2-(Acetylthiomethyl)-1-oxo-3-phenylpropyl]glycine; Ecadotrilum; Ecadotrilo; Ecadotrilum [INN-Latin]; Ecadotrilo [INN-Spanish]; Racecadotril Impurity; NEP Inhibitor
EINECS	Contact for details

Quality Control

Our Ecadotril is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.