Description

Candoxatril CAS NO 123122-55-4 is a potent and selective inhibitor of neutral endopeptidase (NEP), an enzyme involved in the degradation of natriuretic peptides. This compound is of significant interest in pharmaceutical research for its potential role in modulating cardiovascular and renal function. It serves as a critical intermediate and reference standard for researchers and manufacturers developing novel therapeutic agents targeting hypertension and heart failure.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced drug candidates targeting neutral endopeptidase (NEP).
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Biochemical Research: A vital tool for in vitro and in vivo studies investigating the NEP enzyme pathway, natriuretic peptide biology, and related cardiovascular mechanisms.
• Preclinical Development: Employed in pharmacological and toxicological studies to evaluate the efficacy and safety profiles of new NEP inhibitor compounds.

Basic Information

Product Name	Candoxatril
CAS No.	123122-55-4
Molecular Formula	C23H28N2O5
Molecular Weight	412.48 g/mol
Synonyms	(S)-2-((S)-2-((1-Carboxy-2-phenylethyl)amino)propanamido)-3-(4-hydroxyphenyl)propanoic acid; UK-79,300; Candoxatrilat prodrug; NEP Inhibitor UK-79300; (2S)-2-[[(2S)-2-[[2-[(2S)-2-Amino-3-phenylpropanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Candoxatril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.