Description

L-Pimobendan is a highly selective and potent phosphodiesterase III (PDE III) inhibitor with calcium-sensitizing properties. This compound is of significant commercial and research interest for its specific pharmacological activity. It is primarily utilized in the pharmaceutical industry for the development and production of veterinary and human cardiovascular therapeutics. Its targeted mechanism makes it a critical intermediate and active pharmaceutical ingredient (API) for specialized drug formulations.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the manufacture of finished dosage forms for veterinary cardiology.
• Veterinary Pharmaceuticals: Key component in medications for the management of congestive heart failure (CHF) in dogs, specifically to improve cardiac contractility and vasodilation.
• Pharmaceutical Research & Development: Serves as a critical reference standard and building block in preclinical and clinical studies for new cardiovascular drugs.
• Chemical Synthesis Intermediate: Used in organic synthesis for creating novel analogs and derivatives with potential therapeutic applications.
• Biochemical Research: Tool compound for studying PDE III enzyme inhibition and calcium sensitization pathways in cardiac muscle.
• GMP Manufacturing: Supplied for use in Good Manufacturing Practice (GMP) compliant production lines for regulated markets.

Basic Information

Product Name	L-Pimobendan
CAS No.	118428-37-8
Molecular Formula	C19H18N4O2
Molecular Weight	334.37 g/mol
Synonyms	Pimobendan; (R)-Pimobendan; (+)-Pimobendan; 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone; UD-CG 212; Vetmedin (brand name); 6-[2-(p-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
EINECS	Contact for details

Quality Control

Our L-Pimobendan is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, targeting pharmaceutical-grade standards. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques like HPLC and NMR. We support compliance with GMP, ICH Q7 guidelines, and relevant pharmacopeial requirements (e.g., USP, EP) for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Optical Rotation	[α]20/D: +140° to +150° (c=1 in methanol)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.