Description

Eplerenone is a selective aldosterone receptor antagonist, a key pharmaceutical active ingredient used in the treatment of cardiovascular conditions. Its primary value lies in its ability to effectively manage hypertension and heart failure by blocking the harmful effects of aldosterone, offering a targeted therapeutic approach with a favorable side-effect profile. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular medications, including generic and branded drug formulations.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient in finished dosage forms for the treatment of hypertension and congestive heart failure.
• Generic Drug Manufacturing: Critical raw material for the production of generic versions of aldosterone antagonist medications.
• Clinical Research: Used in preclinical and clinical studies to investigate new therapeutic applications for cardiovascular and renal diseases.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for method development and validation.
• Formulation Development: Utilized in R&D for developing new drug delivery systems, such as controlled-release tablets.

Basic Information

Product Name	Eplerenone
CAS No.	107724-20-9
Molecular Formula	C24H30O6
Molecular Weight	414.49 g/mol
Synonyms	9,11α-Epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone; CGP-30083; SC-66110; Inspra; Eple; Eplerenonum; Eplerenona
EINECS	Contact for details

Quality Control

Our Eplerenone is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. Certificates of Analysis (COA) documenting compliance with in-house specifications are available for every shipment. We support customer audits and can provide materials to aid in regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.