Description

Cilobradine CAS NO 109859-50-9 is a high-purity pharmaceutical intermediate and research chemical belonging to the class of bradycardic agents. This compound is of significant interest for its role in the development and synthesis of novel cardiovascular therapeutics, specifically as an If channel inhibitor. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) for heart rate control.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced cardiovascular drugs targeting heart rhythm disorders.
• Research & Development: Used in preclinical and pharmacological studies to investigate If channel (funny channel) inhibition and its effects on cardiac pacemaker activity.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Research: Employed in studies exploring sinus node function and the development of heart rate-lowering agents.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized compounds for clinical trials.

Basic Information

Product Name	Cilobradine
CAS No.	109859-50-9
Molecular Formula	C19H28N2O3
Molecular Weight	332.44 g/mol
Synonyms	4,5-Dimethoxy-3-(1-piperidinylmethyl)benzonitrile; BDF 9195; Cilobradine Hydrochloride (salt form); Zatebradine (related compound); If Channel Inhibitor; Bradycardic Agent; Sinu node inhibitor
EINECS	Contact for details

Quality Control

Our Cilobradine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.