Description

Candoxatrilat is the active metabolite of the prodrug candoxatril, functioning as a potent and selective inhibitor of neutral endopeptidase (NEP). This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for cardiovascular and renal therapies. It is essential for researchers and manufacturers developing novel vasopeptidase inhibitors and studying the natriuretic peptide system. The product, identified as Candoxatrilat CAS NO 123122-54-3, is supplied to meet the stringent requirements of the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control in API and finished drug product manufacturing.
• Cardiovascular Research: Used as a key pharmacological tool to study the role of NEP inhibition in conditions like hypertension and heart failure.
• Active Pharmaceutical Ingredient (API) Intermediate: A vital synthetic building block in the production pathway for advanced NEP inhibitor drugs.
• Biochemical Assay Development: Employed in high-throughput screening and enzymatic assays to discover and optimize new therapeutic candidates.
• Metabolite Studies: Crucial for pharmacokinetic and pharmacodynamic research to understand the in vivo activity and profile of candoxatril.
• Academic and Institutional Research: Supports fundamental scientific investigations into peptide hormone metabolism and signal transduction pathways.

Basic Information

Product Name	Candoxatrilat
CAS No.	123122-54-3
Molecular Formula	C23H30N2O5
Molecular Weight	414.50 g/mol
Synonyms	(2R,4R)-4-([1,1'-Biphenyl]-4-yl)-2-[(phenylcarbonyl)amino]-5-oxopentanoic Acid; UK-73967; Candoxatrilat Acid; UK 73967; (2R,4R)-4-([1,1'-Biphenyl]-4-yl)-2-(benzoylamino)-5-oxopentanoic Acid; N-[(2R,4R)-4-(4-Biphenylyl)-5-oxo-2-tetrahydrofuranyl]benzamide
EINECS	Contact for details

Quality Control

Our Candoxatrilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.